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美国医疗业:如何看待波动中空间

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美国医疗业:如何看待波动中空间

 

 North America Equity Research March 13, 2020

 US Healthcare How We Are Thinking About The Space In The Midst Of Volatility

 Pharmaceuticals Chris Schott, CFA AC (1-212) 622-5676 US Biotechnology Cory Kasimov AC 212-622-5266 HC Technology & Distribution Lisa Gill AC

 212-622-6466 HC Facilities & Managed Care Gary Taylor AC

 +1 212-622-6600 christopher.t.schott@jpmorgan.com

 cory.w.kasimov@jpmorgan.com lisa.c.gill@jpmorgan.com| gary.taylor@jpmorgan.com

 US SMID Biotechnology Jessica Fye AC

 212-622-4165 jessica.m.fye@jpmorgan.com Eric Joseph, PhD AC

 212-622-0659 eric.w.joseph@jpmorgan.com

 Anupam Rama AC

 212-622-0900 anupam.rama@jpmorgan.com Medical Supplies & Devices Robbie Marcus, CFA AC

 (1-212) 622-6657 Robert.j.marcus@jpmorgan.com Life Science Tools & Diagnostics Tycho Peterson AC

 +1 212 622 6568 Tycho.peterson@jpmorgan.com

 See the end pages of this presentation for analyst certification and important disclosures, including non-US analyst disclosures. J.P. Morgan does and seeks to do business with companies covered in its research reports. As a result, investors should be aware that the firm may have a conflict of interest that could affect the objectivity of this report. Investors should consider this report as only a single factor in making their investment decision.

 COVID-19

 Impact

 on

 Fundamental

 Visibility

  (1) Pharma pg. 10 (2) Large Biotech pg. 13 (1) Healthcare Facilities & Managed Care pg. 26 (2) MedTech pg. 32 JP Morgan Cross-Sector Healthcare Summary

 

 The

 global

 COVID-19

 pandemic

 represents

 a

 fluid

 situation

 characterized

 by

 incomplete

 but

 rapidly evolving

 data

 from

 disparate

 sources.

 The

 JP

 Morgan

 U.S.

 healthcare

 team

 generally

 acknowledges

 the high

 level

 of

 uncertainty

 and

 the

 strong

 likelihood

 of

 accelerating

 U.S.

 incidence

 growth

 over

 the

 next several

 months.

 This

 deck

 represents

 the

 team’s

 current

 thinking.

  FUNDAMENTAL

 VISIBILITY

 (by

 Sector)

 HIGHEST

 INTERMEDIATE

 (1) Life Science Tools & Diagnostics pg. 20 (2) Healthcare Technology & Distribution pg. 23 (3) SMID Biotech pg. 16/17/18

  LOWEST

 2

  With

 the

 COVID-19

 pandemic

 spreading

 globally

 and

 triggering

 extended

 market

 volatility

 the

 past few

 weeks,

 we

 wanted

 to

 provide

 an

 overview

 of

 the

 development

 of

 the

 outbreak

 and

 share

 some thoughts

 on

 how

 we

 are

 thinking

 about

 the

 sector’s

 exposure

 in

 general

 as

 well

 as

 how

 to

 position in

 the

 space.

 Overall,

 we

 see

 the

 healthcare

 sector

 as

 relatively

 better-positioned

 compared

 to

 the

 broader

 market in

 the

 midst

 of

 this

 pandemic

 (a

 view

 reinforced

 by

 the

 past

 two

 weeks

 with

 healthcare

 down

 ~19%

 in the

 last

 month

 vs

 ~26%

 for

 the

 market)

 with

 demand

 for

 care

 and

 drugs

 remaining

 fairly

 inelastic overall.

 On

 specific

 subsector

 exposure

 and

 positioning,

 we

 expect

 biopharma

 to

 have

 least exposure

 to

 COVID-19

 while….

 

 Pharma:

 We

 expect

 COVID-19

 to

 have

 little

 impact

 to

 results

 and

 see

 demand

 for

 prescription medication

 as

 fairly

 inelastic.

 That

 said,

 certain

 therapeutic

 areas

 (e.g.

 Oncology)

 will

 be

 more

 resilient than

 others

 (e.g.

 Primary

 care)

 if

 the

 pandemic

 prolongs.

 

 Like

 pharma,

 we

 expect

 a

 modest

 impact

 on

 Biotech

 commercial

 products

 given

 the

 inelasticity

 of demand

 (though

 somewhat

 dependent

 on

 disease

 severity

 /

 patient

 pop)

 and

 anticipate

 little

 in

 the

 way of

 drug

 shortages

 from

 COVID-19

 disruptions.

 The

 bigger

 unknowns,

 in

 our

 view,

 revolve

 around

 impact on

 clinical

 and

 regulatory

 timelines,

 access

 to

 capital

 markets,

 and

 BD

 activities.

 

 For

 Life

 Science

 Tools

 &

 Diagnostics ,

 not

 surprisingly,

 tools

 and

 med

 tech

 are

 seeing

 the

 greatest COVID-19

 impact,

 while

 CROs

 have

 benefitted

 from

 relative

 insulation.

 Despite

 a

 YTD

 correction, valuations

 remain

 rich

 (~16x

 NTM

 EBITDA

 for

 core

 tools)

 with

 expected

 financial

 resets

 still

 to

 come from

 both

 the

 direct

 COVID-19

 impact

 and

 derivatives

 (oil

 price

 volatility,

 potential

 U.S.

 academic slowdown,

 etc.)

 and

 as

 such,

 we

 recommend

 select

 exposure,

 including

 diversified

 names

 (DHR, AVTR),

 CRO/CDMOs

 (PPD,

 IQV,

 CTLT)

 and

 U.S.-focused

 growth

 stories

 (ADPT,

 GH,

 NSTG,

 TXG).

  

 The

 impact

 of

 COVID-19

 will

 likely

 be

 mixed

 across

 the

 Healthcare

 Technology

 &

 Distribution

 space, with

 the

 biggest

 beneficiaries

 in

 our

 view

 telehealth

 providers

 TDOC

 and

 ONEM

 given

 the

 ability

 to

 treat patients

 in

 a

 virtual

 setting.

  By

 sub-sector,

 availability

 of

 supply

 will

 dictate

 the

 impact

 to

 the pharmaceutical

 and

 medical

 distributors,

 retail

 pharmacies

 could

 see

 curtailed

 visits

 but

 an

 uptick

 in

 mail order/home

 delivery

 scripts,

 and

 the

 labs

 could

 see

 a

 small

 benefit

 from

 COVID-19

 testing,

 offset

 by reduced

 routine/wellness

 testing

 in

 the

 near

 term.

  Longer

 term,

 we

 continue

 to

 favor

 names

 that

 are

 at the

 intersection

 of

 cost,

 quality

 and

 convenience,

 with

 CVS

 our

 top

 pick.

 

 Healthcare

 Facilities

 &

 Managed

 Care

 are

 the

 epicenter

 of

 the

 U.S.

 healthcare

 system

 response

 to Covid-19

 (i.e.

 who

 is

 going

 to

 treat

 the

 patients

 and

 who

 is

 going

 to

 pay).

 In

 the

 near-term

 (possibly through

 2Q20),

 we

 expect

 deferred

 procedures

 to

 exceed

 actual

 virus

 treatment

 costs

 (hospitals

 are

 hurt while

 managed

 care

 benefits).

 In

 the

 worst-case

 scenario;

 hospital

 losses

 would

 build

 and

 payor

 loss ratios

 would

 increase

 –

 thus

 the

 near-term

 trade

 is

 data-dependent

 and

 likely

 lower.

 However

 with

 a

 6- 12month

 view,

 we

 see

 a

 very

 attractive

 investment

 opportunity

 across

 nearly

 the

 entire

 sector

 as

 this overhang

 ultimately

 lifts.

 

 COVID-19

 is

 likely

 to

 have

 a

 measurable

 effect

 on

 the

 MedTech

 space

 as

 elective

 and postponable/elective

 procedures

 are

 likely

 to

 take

 a

 sizeable

 hit.

  Elective

 procedures

 in

 China

 had almost

 completely

 stopped

 in

 February

 (down

 80-90%),

 and

 we

 expect

 to

 see

 significant

 procedure delays

 and/or

 cancellations

 in

 other

 markets

 as

 the

 virus

 proliferates.

 However,

 it’s

 important

 to

 note

 that exposure

 to

 elective

 procedures

 varies

 significantly

 within

 our

 coverage,

 with

 some

 names

 fully

 exposed and

 others

 almost

 entirely

 insulated.

 At

 the

 same

 time,

 we

 note

 that

 the

 majority

 of

 product manufactured

 in

 China

 is

 then

 sold

 in

 the

 region,

 limiting

 the

 potential

 supply

 disruption

 to

 the

 rest

 of

 the business.

 Insulet

 is

 the

 exception,

 though

 for

 now

 supply

 isn’t

 negatively

 impacted.

  

 BASIC

 STATS

 COVID-19:

 

 The

 U.S.

 currently

 has

 ~1,663+

 confirmed

 reported

 cases.

 Based

 on

 experience

 from

 other

 countries

 (China, Italy,

 South

 Korea,

 Iran),

 we

 could

 expect

 the

 following

 scenario

 in

 the

 U.S.

 and/or

 other

 countries

 who

 have

 not yet

 experienced

 a

 surge: o

 Potential

 Scenario:

 (1)

 A

 country/region

 reaches

 several

 hundred

 reported

 cases,

 (2)

 COVID-19

 testing becomes

 widely

 available

 to

 the

 public,

 (3)

 Strong

 growth

 (potentially

 exponential)

 of

 reported

 cases

 to

 occur over

 the

 coming

 weeks

 with

 a

 doubling

 of

 cases

 every

 few

 days.

 

 Early

 research

 from

 experts

 suggest

 COVID-19

 is

 not

 only

 more

 contagious

 (each

 contracted

 person

 is

 likely

 to infect

 2-4

 people)

 than

 the

 Flu

 (1.5-3

 people)

 but

 also

 more

 deadly

 (estimated

 fatality

 rates

 currently

 ranging from

 below

 1%

 in

 some

 countries

 to

 ~3-4%

 in

 others

 vs

 ~0.1%

 seasonal

 Flu). 

 POSITIVE

 DEVELOPMENTS:

 

 Virus

 Containment:

 The

 number

 of

 new

 cases

 in

 Asia

 (China,

 S.

 Korea,

 SGP,

 HK)

 are

 currently

 dropping

 with the

 cumulative

 total

 cases

 beginning

 to

 see

 a

 potential

 plateau

 (China

 and

 S.

 Korea). 

 Vaccine/Drug

 Development:

 Seeing

 strong

 collaborative

 efforts

 worldwide

 around

 vaccine/drug

 development and

 accelerated

 testing

 driving

 significant

 innovation

 with

 the

 growing

 possibility

 of

 achieving

 a

 working

 vaccine or

 therapeutic

 sometime

 in

 the

 near

 future. 

 The

 U.S.

 has

 implemented

 a

 rigorous

 public

 health

 response

 (limits

 on

 travel

 and

 large

 group

 events)  

 NOTABLE

 “UNKNOWNS”

 LIMITING

 CAPABILITY

 TO

 QUANTIFY

 FINANCIAL

 IMPACT:

 

 Penetration

 rates

 within

 populations,

 with

 public

 demographics

 (age),

 behavior

 (smoking)

 and

 public

 health actions

 (testing,

 hygiene,

 social

 distancing

 and

 quarantine)

 seemingly

 having

 a

 material

 impact

 on

 incidence and

 prevalence

 of

 the

 virus 

 Impact

 of

 non-urgent

 procedure

 deferrals

 from

 compromised

 individuals

 and/or

 fear

 of

 infection 

 Potential

 disruption

 of

 healthcare

 supply

 chain

 (i.e.

 supply

 shortages,

 ICU

 capacity,

 labor

 availability,

 etc…) 

  

 KEY

 FACTORS:

 1) Transmissibility

 -

  Emerging

 data,

 modestly

 more

 transmissible

 than

 seasonal

 influenza

 2) Severity

 –

 Higher

 severity/fatality

 rate

 for

 10-20%,

 generally

 less

 severe/symptomatic

 than

 flu

 for

 80%

 3) Penetration

 –

 Reliable

 data

 only

 from

 China

 and

 South

 Korea

 who

 have

 conducted

 widespread

 testing, but

 emerging

 data

 suggests

 elderly/smokers/immune-compromised

 individuals

 are

 more

 susceptible. Public

 health

 measures/restrictions

 are

 likely

 to

 have

 the

 greatest

 impact

 on

 population

 penetration

 in the

 near-term.

 Longer-term

 penetration

 will

 likely

 be

 dictated

 by

 the

 likely

 development

 of

 treatment regimens

 and

 vaccines.

 

 CONTEXT/PERSPECTIVE/EXTRAPOLATION:

 

 Epidemiological

 experts

 (Lawler

 &

 Osterholm

 for

 example)

 have

 predicted

 ~5-50m

 U.S.

 hospitalizations. The

 range

 of

 estimates

 is

 hyperbolic,

 obviously

 contributing

 to

 the

 current

 uncertainty. 

 On

 the

 other

 hand,

 our

 population

 based

 extrapolation

 from

 China,

 South

 Korea

 &

 Italy

 would

 suggest 50-400k

 U.S.

 cases,

 5-80k

 U.S.

 hospitalizations

 and

 0.4-26k

 U.S.

 deaths.

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